Tuesday, February 06, 2007

Everyone else is repeating it, so will I.... Cheap Cancer Drug


Cheap, Safe, Patentless Cancer Drug Discovered
Posted by Zonk on Tuesday February 06, @01:41AM from the an-age-of-medical-marvels dept. 
PyroMosh writes"The New Scientist is reporting that researchers working at the University of Alberta in Edmonton, Canada have discovered that an existing drug called dichloroacetate (DCA) is effective in killing cancer cells, while leaving the host's healthy cells unharmed. DCA has already been used for years to treat metabolic disorders, and is known to be fairly safe. Sounds like great news, is it too good to be true? Why is the mainstream news media failing to report on this potential breakthrough? The University of Alberta and the Alberta Cancer Board have set up a site with more info, where you can also donate to support future clinical trials."


AND



Cheap, Safe Drug Kills Most Cancers General | Posted by Max at Feb. 6, 2007 - 3:14 am DCA attacks a unique feature of cancer cells: the fact that they make their energy throughout the main body of the cell, rather than in distinct organelles called mitochondria. This process, called glycolysis, is inefficient and uses up vast amounts of sugar. Until now it had been assumed that cancer cells used glycolysis because their mitochondria were irreparably damaged. However, Michelakis's experiments prove this is not the case, because DCA reawakened the mitochondria in cancer cells. The cells then withered and died.

Michelakis suggests that the switch to glycolysis as an energy source occurs when cells in the middle of an abnormal but benign lump don't get enough oxygen for their mitochondria to work properly (see Diagram). In order to survive, they switch off their mitochondria and start producing energy through glycolysis.

Crucially, though, mitochondria do another job in cells: they activate apoptosis, the process by which abnormal cells self-destruct. When cells switch mitochondria off, they become "immortal", outliving other cells in the tumour and so becoming dominant. Once reawakened by DCA, mitochondria reactivate apoptosis and order the abnormal cells to die.

Hey, wow. Cool. Everyone cross your fingers and knock on everything wooden.
[Read Full Story at New Scientist]




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